Chase the Case #5 - Acute myeloid leukemia type monoblastic (AML-M5b) -
October 2021 (PDF for print)
Patient Demography: Woman, 67 years old
Diagnosis: Acute myeloid leukemia (AML) type monoblastic
Observation: Fortuitous discovery of AML in immediate post surgery with bilateral adnexectomy for ovarian carcinoma in a woman with mutated BRCA1 and no previous treatment. Persistent anemia and thrombopenia, rapid increase in WBC and blast cell appearance in blood led to bone marrow examination confirming the diagnosis of monoblastic AML (81 % blast and monoblast).
Other Tests Information: Hemoglobin = 90 g/L, platelet = 59 G/L; Leucocytes = Day-1 : 3.0 G/L with monocyte 15.7%, Day-3 : 3.6 G/L with 12% blast cell and monoblast ,14,1% monocyte and promonocyte, Day-7 : 15.8 G/L with 47.3% blast cell and monoblast, 17.3% monocyte and promonocyte; BM Caryotype = normal; BM Molecular genetics = Mutated NPM1 and FLT3.
Microscopic count: Monocytes and promonocytes 18.3%; Blast cells and monoblast 52%
This clinical case is provided by Durrieu Francoise, Institute Bergonié (Institut Bergonié), Bordeaux, France.
